Synthesis of Dialkyl 2-(4-oxopyridin-1(4H)-yl)dicarboxylates Through the Reaction of 4-hydroxypyridine and Dialkyl Acetylenedicarboxylate in the Presence of Triphenylphosphine

Abstract

Hydroxypyridine undergoes a smooth reaction with dial- kyl acetylenedicarboxylates in the presence of triphenylphosphine (15 mol %) to produce the E/Z isomers of dialkyl 2-(4-oxopyridin-1(4H)- yl)but-2-enedioates in high yields.