Abstract
1. We synthesized the cis-3-[di(2-chloroethyl) amino] cyclohexylcarboxylic, cis-4-[di-(2-chloroethyl)amino] cyclohexylcarboxylic, and cis-4-[di-(2-chloroethyl) amino]cyclohexylacetic acids, and also their ethyl esters, both as the hydrochlorides and as the free bases. 2. The acylation of the esters of DL-phenylalanine and DL-valine by the carbodiimide method proceeds only in the case where the amino group of cis-4-[di-(2-chloroethyl)amino]-cyclohexylacetic acid is protonated. The hydrochlorides of N-cis-4-[di-(2-chloroethyl)-amino] cyclohexylacetyl-DL-phenylalanine and N-cis-4-[di-(2-chloroethyl) amino] cyclohexylacetyl-DL-valine were synthesized by removing the benzyl and benzhydryl C-protective groups from the corresponding esters.
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