Synthesis of Dendrimers by Homocoupling of Alkyne-focal Frechet Type Dendrons

Abstract

we are fascinated to develop the new click chemistry for the construction of dendri-mers using oxidative homocoupling reaction of the terminal acetylene. In this paper, we report a feasible route to synthesize the symmetric Frechet type dendrimers from Frechet type dendrons containing alkyne moiety at their focal point by oxida-tive homocoupling of terminal alkyne. Because dendrimers contain three distinct structural parts that are the core, end-groups, and branched units connecting core and periphery, we became interested in the synthesis of self-emissive dendrimer with a fluorescent probe in core region. A relatively few applications using the alkynyl-dendron in dendrimer synthesis have been reported. The palladium-cataly-zed coupling of terminal acetylenes to aromatic bromides or iodides in basic amines have been well known since 1975.