Abstract
AbstractStarting from R,R‐(+)‐tartaric acid, the synthesis of (2S,3R,4R6E)‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid in 24 steps is reported. This novel amino acid is found in the cyclic undecapeptide cyclosporin A, isolated from the fungal strain Tolypocladium inflatum GAMS. Its stereospecific synthesis allowed, for the first time, the isolation and characterization of the new amino acid previously reported as the ‘C‐9‐amino acid’ [1].
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