Abstract
AbstractCyclobutanes and cyclobutenes exhibit intriguing structures and demonstrate significant biological activities and diverse synthetic applications. This review aims to summarize recent progress in strain-release-driven ring-opening reactions of bicyclo[1.1.0]butanes (BCBs) to synthesize these four-membered carbon rings. It outlines the strategies, regio- and stereoselectivity, the synthetic scope of reactions, and the mechanistic implications of the catalytic ring-opening process, providing a supplementary perspective to existing reviews.1 Introduction2 Thermally Driven Nucleophilic Ring-Opening3 Thermally Driven Rearrangement and Isomerization Reaction4 Light-Driven Ring-Opening5 Transition-Metal/Lewis Acid Catalyzed Ring-Opening6 Conclusion and Outlook
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