Abstract
In this study, a simple chemical reduction method was employed to synthesize CuO-NPs. Various dicarboxylic acids were converted into Cu(II) salt of dicarboxylic acid which were used as precursors. NPs were produced by reducing precursors with NaBH4. Characteristics of synthesized NPs were investigated by using important analytical techniques including Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermo gravimetric analysis (TGA) and scanning electron microscopy (SEM). Developed NPs were investigated for their antibacterial activity against a range of bacterial strains by employing agar well diffusion method. CuO-NPs exhibited good to moderate activity against E-Coli, B. Subtilis and poor activity against K. pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). It was found that amongst all experienced compounds sample 2 showed good activity with minimum inhibition concentration (MIC) 10 µg/mL (zone of inhibition: 22± 0.12 mm) while sample 3 showed poor activity with MIC 40 µg/mL (zone of inhibition: 8.0 ± 0.18 mm).
 
 KEY WORDS: CuO-NPs, Dicarboxylic acids, Sodium borohydride, Antibacterial study
 
 Bull. Chem. Soc. Ethiop. 2020, 34(2), 323-334
 DOI: https://dx.doi.org/10.4314/bcse.v34i2.10
Highlights
A day’s modern research is revolving around nanotechnology because nanoparticles have unique catalytic [1] and bio-medical applications [2, 3]
Copper oxides NPs are used for gas sensors [4], photovoltaic solar cell [5, 6], photo electrochemical cell [7, 8] and electro-chromic coatings [9]
Antimicrobial study of synthesized NPs was based on following steps: Preparation of the test compound mg of NPs were dissolved in 1 mL of ethanol which was further diluted of varying concentrations, i.e. (0.2 mg/0.1 mL, 0.02 mg/0.1 mL, and 0.002 mg/0.1 mL) for microbiological assays
Summary
A day’s modern research is revolving around nanotechnology because nanoparticles have unique catalytic [1] and bio-medical applications [2, 3]. CuO-NPs are of great interest than other metal NPs due to its low cost and easy availability. Copper oxide nanomaterials have been developed substantially in recent years due to its low cost fabrication and good electrochemical properties. Copper oxides NPs are used for gas sensors [4], photovoltaic solar cell [5, 6], photo electrochemical cell [7, 8] and electro-chromic coatings [9]. Metal oxide NPs mainly dragged the attention of researchers due to their medicinal applications. Metallic NPs have immense surface area and this surface area and particle size play a key role in medicinal, catalytic activities and photocatalytic degradation [13], that is why comparison of metallic NPs surface area with conventional materials have been intensely investigated [14]
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