Abstract
Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
Highlights
The development of sensitive chemosensors is an active field of research in recent years because of their potential application in clinical biochemistry as well as analytical chemistry and environmental science [1,2,3]
It is declared in the literature that different ligands and different complexes synthesized from same ligands with different metal ions possess different biological properties [12,14,15]
The newly prepared compounds may be more effective than known others in terms of their biological activities and possibly display their efficiencies with a distinct mechanism from those of well known, we describes the synthesis of Cu(II), Ni(II), Co(II) and Mn(II) complexes from bromocoumarin and ciprofloxacin as ligand
Summary
The development of sensitive chemosensors is an active field of research in recent years because of their potential application in clinical biochemistry as well as analytical chemistry and environmental science [1,2,3]. In 2002, Turel [8] reviewed the synthesis, physico-chemical properties, and structural characteristics of several binary and ternary fluoroquinolone compounds, together with their biological activity. The interactions of quinolones and metal ions have been thoroughly studied especially due to the interesting biological and chemical properties Ciprofloxacin can usually act as a bidentate ligand through the pyridone oxygen and one carboxylate oxygen. It is declared in the literature that different ligands and different complexes synthesized from same ligands with different metal ions possess different biological properties [12,14,15]. The newly prepared compounds may be more effective than known others in terms of their biological activities and possibly display their efficiencies with a distinct mechanism from those of well known, we describes the synthesis of Cu(II), Ni(II), Co(II) and Mn(II) complexes from bromocoumarin and ciprofloxacin as ligand.
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