Synthesis of covalently linked double-helical cross sections representative of purine-pyrimidine, purine-purine, and pyrimidine-pyrimidine duplexes

Abstract

Here described are the syntheses of (1) covalently linked cross sections with molecular architecture similar to Watson-Crick hydrogen-bonded purine-pyrimidine base pairs in NRA, DNA, and RNA/DNA double helices; (2) covalently linked purine-purine cross sections with dimensions such as would be produced in the pairing of A with I or G, generating a bulge in double-helical RNA or DNA; and (3) covalently linked pyrimidine-pyrimidine cross sections with dimensions such as might be produced in the hypothetical pairing of C with U or T, namely, a pinched-in RNA or DNA cross section