Synthesis of core-shell-like structure SnS2-SnO2 integrated with graphene nanosheets for the electrochemical detection of furazolidone drug in furoxone tablet

Abstract

Trace level evaluation in analysis is an important step to construct a viable sensor. Here, the proposed furazolidone (FZD) sensor was developed electrochemically using an SnS2-SnO2/graphene composite. The formation of the SnS2-SnO2/graphene composite was confirmed by physical characterizations such as X-ray crystallography (XRD), Scanning Electron Microscope (SEM), and Fourier Transform InfraRed (FT-IR) Spectroscopy. The newly synthesized SnS2-SnO2/graphene composite was drop-casted on a glassy carbon electrode (GCE) surface to investigate the electrochemical oxidation of FZD using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods with the best working potential at −0.516 (vs. Ag/AgCl) in 0.1 M PB solution (pH 7.0). Using CV, different modified electrodes, different addition, scan rates, and pH studies were investigated to study peak current effects. The obtained DPV results at the SnS2-SnO2/graphene composite exhibited a lower limit of detection (LOD) (1.42 nM), good linear range, high selectivity, short-time response (˂1 s), better repeatability, reproducibility, and enduring stability. In addition, the fabricated SnS2-SnO2/graphene/GCE was used to determine the FZD in a commercially available furoxone tablet.