Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity.

E S Shchegravina,D N Shcherbakov,E A Sharlaeva,S V Belenkaya,A R Sitdikova,S D Usova,N F Salakhutdinov,V Yu Chirkova,E S Mozhaitsev,E V Svirshchevskaya,I P Fonareva,D S Baev,A Yu Fedorov,E A Volosnikova,O I Yarovaya

doi:10.1007/s11172-023-3730-4

Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity.

E S Shchegravina, D N Shcherbakov + Show 13 more

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https://doi.org/10.1007/s11172-023-3730-4

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Journal: Bulletin of the Academy of Sciences of the USSR, Division of chemical science	Publication Date: Jan 1, 2023
Citations: 5

Affiliation: State Research Center of Virology and Biotechnology VECTOR, Novosibirsk State University, N. I. Lobachevsky State University of Nizhny Novgorod, Altai State University, Institute of Bioorganic Chemistry

#Main Viral Protease #Bicyclic Monoterpenoids + Show 8 more

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Abstract

Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

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