Abstract
Terminal alkynes can be coupled with alkenyl iodides under copper(I) catalysis, affording the corresponding enynes in good to excellent yields with retention of the double-bond configuration. Many of these products are of interest for pharmacology and materials science. Substituted o-bromotrifluoroacetanilides react with 1-alkynes to 2-substituted indoles. This type of Sonogashira coupling does not use expensive Pd catalysts and is therefore more convenient for large-scale industrial applications than most of the existing protocols.
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