Synthesis of Clean Cabbagelike (111) Faceted Silver Crystals for Efficient Surface-Enhanced Raman Scattering Sensing of Papaverine.

Abstract

Clean cabbagelike (111) faceted silver crystals were synthesized via a facile galvanic replacement reaction of [Ag(NH3)2]OH and a commercial aluminum foil, a surfactant-free formation process. The cabbagelike silver crystals consisted of interconnected nanoplates and exhibited a single-crystal structure along with preferential (111) facet oriented growth. These silver crystals showed high and reliable surface-enhanced Raman scattering (SERS) activity due to electromagnetic mechanism, and they could be easily transferred onto other rigid or flexible surfaces, making their SERS applications more versatile. Since Ag (111) with low surface energy could preferentially adsorb papaverine molecules, which was verified by molecular dynamics simulation, the cabbagelike silver crystals were further employed as a promising SERS assay for efficient sensing of papaverine, a nonnarcotic alkaloid. A linear range of 0.1-1000 μM was achieved, along with a detection limit of 10 nM and good selectivity relative to other excitability drugs. This SERS assay has successfully been used to determine the concentration of papaverine in hot pot seasonings and drugs with satisfactory recoveries and relative standard deviations.