Abstract

5a-Amino-5aH,11H-chromeno[2,3-b]chromene-11a(12H)-carbonitriles were synthesized from malono-nitrile and o-quinone methides, generated in situ by the thermolysis of phenolic Mannich bases in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene. It was also shown that this heterocyclic system can be obtained from 2-amino-4H-chromene-3-carbonitriles and the aforementioned o-quinone methides.

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