Abstract
Sulfonimidamides, the aza-analogues of sulfonamides, have been of interests as chiral nitrene precursors and due to their bioactivities. However, their application as chiral ligands in asymmetric metal catalysis has not yet been fully explored. The authors have developed two synthetic routes for the synthesis of enantiopure amino-functionalized sulfonimidamides 4 from readily available materials. These compounds have been successfully employed as chiral ligands in asymmetric copper-catalyzed Henry reactions to afford good yields and up to 95% ee.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
