Abstract
AbstractA versatile and efficient strategy for the total synthesis of the anti‐HIV‐1 agent concentricolide and its analogues daldinins A, B, and C has been established. This strategy offers a mild and facile access to these benzo annulated compounds, bearing multiple stereocenters in good yield with 99% enantiomeric excess (ee) and 93% diastereomeric excess (de) values. Construction of the corresponding syn dihydrobenzofuran and phthalide groups can be achieved in one step by Noyori's asymmetric transfer hydrogenation, via dynamic kinetic resolution.magnified image
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.