Synthesis of chiral γ-sultams through intramolecular reductive amination with sulfonylcarbamate as N-source

Abstract

An efficient and enantioselective palladium-catalyzed intramolecular asymmetric reductive amination with sulfonylcarbamates as N-sources was reported, providing a facile and general access to the chiral γ-sultam derivatives with up to 97% of enantioselectivity. This tandem process avoids additional deprotection manipulation and arduous isolation of the N-sulfonyl-imine intermediates.