Abstract

The total enantioselective synthesis of (−)-chanoclavine I 2 in twelve steps from indole-4-carboxaldehyde 4 is described The key-step 3 → 6 which involves the formation of the C ring by creation of the C5-C10 bond is catalyzed by a chiral palladium (0) complexes. The chiral ergoline synthon 6 is produced with an excellent diastereo-and enantioselectivity (up to 95% ee).

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