Synthesis of carnation-like Ho3+/Co3O4 nanoflowers as a modifier for electrochemical determination of chloramphenicol in eye drop

Abstract

A simple solvo-thermal strategy and different analytical techniques were applied for synthesizing carnation-like Ho3+/Co3O4 nanoflowers (CL-Ho3+/Co3O4-NFs). This research explained using a glassy carbon electrode (GCE) modified by Ho3+/Co3O4 nanoflowers to detect chloramphenicol. Such nanoflowers presented acceptable catalytic activities to determine chloramphenicol by cyclic voltammetry (CV) and different pulse voltammetry (DPV) techniques. Functions of the modified electrode has been dealt with through electrochemical impedance spectroscopy (EIS). Under optimal pH = 7.0, chloramphenicol reduction was observed at a potential approximately 267 mV less positive compared to the unmodified electrode. Considering DPV, chloramphenicol reduction showed a dynamic range of 0.01–800.0 µM and a limit of detection (3 s) of 7.1 nM. The research found an acceptable function of the modified electrode to detect chloramphenicol in real samples via the standard addition method.