Abstract
The mannose monosaccharide derivative, acetylthiopropyl 2,3,4,6-tetra- O-acetyl-α- d-mannopyranoside (Man), and the mannobiose derivative, acetylthiopropyl 2,4,6-tri- O-acetyl-3- O-(2′,3′,4′,6′-tetra- O-acetyl-α- d-mannopyranosyl)-α- d-mannopyranoside (α-1,3-Man), were synthesized respectively. These mannose derivatives were introduced into carbosilane dendrimer scaffolds of the zero and first generations. As a result, six carbosilane dendrimers were functionalized by Man and α-1,3-Man. Isothermal titration microcalorimetry was done to determine binding assay between mannose moieties of carbosilane dendrimer and concanavalin A. It was found that carbosilane dendrimers bound more efficiently to concanavalin A than free mannose (Me-α-Man) and mannobiose (Me-α-1,3-Man).
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