Abstract
AbstractAn efficient two‐step synthesis of 8‐chloro‐1‐methyl‐6‐phenyl‐[3H]‐S‐triazolo‐[4,3‐a][1,4]‐benzodiazepine (alprazolam) and 8‐chloro‐6‐(2‐chlorophenyl)‐1‐methyl‐[3H]‐S‐triazolo‐[4,3‐a][1,4]‐benzodiazepine (triazolam) labelled with carbon‐13 or carbon‐14 from their corresponding hydrazines is reported. The method involves acylation of the appropriate hydrazine using the mixed carbonic anhydride of sodium [13C] or [14C] acetate and isobutylchloroformate under mild conditions. Thermolysis of the resulting acetylhydrazides gave the target carbon‐14 and carbon‐13 labelled compounds in good yields.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Labelled Compounds and Radiopharmaceuticals
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.