Abstract
Perfluorocarbon emulsion has been studied as an oxygen carrier, due to its high oxygen content. In clinical trials, it has shown stability in delivering oxygen to the target region. The purpose of the present study was to increase the stability of the emulsion by coating its surface with calcium phosphate. A layer-by-layer method was employed to coat the flexible emulsion surface. Considering the ionic affinity of calcium and phosphate to the lecithin emulsion surface, the first layer of coating was calcium and the second layer was comprised of phosphate ion. The coated emulsion demonstrated various oxygen release times depending on the thickness of the layers: from 0.04 sec. for a thickness of 8 nm to 0.17 sec. for a thickness 38 nm. Overall, the stability of the calcium phosphate coated emulsion was increased, while its original function as an oxygen carrier was maintained.
Highlights
Artificial oxygen carriers are designed to fulfill the oxygen carrying function normally performed by red blood cells (RBCs)
In order to ensure the optimal dispersion of particles, the zeta-potential was monitored as a function of pH, since some type of surface charge was necessary to avoid flocculation, coalescence, or creaming
The binding coefficient of the calcium ion to soy lecithin was studied, using a Hill Plot, to estimate the amount of the calcium that would be needed for a full coating
Summary
Artificial oxygen carriers are designed to fulfill the oxygen carrying function normally performed by red blood cells (RBCs). There are, generally, two types of systems studied, hemoglobin and perfluorocarbon (PFC) based, with many developers concentrating on the PFC emulsion [1]-[6]. The efficacy of the emulsion, is still. How to cite this paper: Han, K.-B., Takagi, C., Wu, C.-J., Mizukami, H. and Ostafin, A. (2016) Synthesis of Calcium Phosphate Controllable Coating Thickness on Oil-in-Water Nanoemulsion with Performance of Oxygen Release as Oxygen Carrier. It is important to produce a stable emulsion system that can withstand various processing and storage conditions. This work created a rigid surface that encapsulated the particle with calcium phosphate and performed the encapsulated particle in stability and as an oxygen carrier
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
