Synthesis of butyl alcohol containing the radioactive carbon isotope C14

Abstract

1. A new method is proposed for the synthesis of butyl alcohol labeled with radiocarbon C14 which is distinguished by simplicity and a yield of product. Two stages are involved: organomagnesium synthesis of butyric acid and its isolation in the form of sodium butyrate, and reduction of the salt with lithium aluminum hydride. The method may be employed for synthesis of various alcohols containing radiocarbon C14. 2. Labeled butyl alcohol can also be prepared without preliminary isolation of butyric acid by direct reduction of the organomagnesium complex with lithium aluminum hydride.