Abstract
The synthesis of bis (1-methyl-2-octynyl) ether using two secondary alcohols under Nicholas reaction conditions is reported. The reaction is possible due to a catalytic participation of the Lewis acid when the nucleophilic alcohol is protected as a THPO-ether.
Highlights
The synthesis of bis (1-methyl-2-octynyl) ether using two secondary alcohols under Nicholas reaction conditions is reported
The reaction is possible due to a catalytic participation of the Lewis acid when the nucleophilic alcohol is protected as a THPO-ether
We report the synthesis of bis (1-methyl-2-octynyl) ether (7) using only the secondary alcohol 1 as electrophile and its O-protected derivative 2 as nucleophile under Nicholas reaction conditions (Scheme 1)
Summary
Abstract: The synthesis of bis (1-methyl-2-octynyl) ether using two secondary alcohols under Nicholas reaction conditions is reported. The reaction is possible due to a catalytic participation of the Lewis acid when the nucleophilic alcohol is protected as a THPO-ether.
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