Synthesis of Biogenic Silver Nanoparticles with Eco-Friendly Processes Using Ganoderma lucidum Extract and Evaluation of Their Theranostic Applications

Vinh Phu Nguyen,Thu Huong Nguyen,Dongquy Hoang,Thai Hoa Tran,Hieu Le Trung,Dong Kee Yi

doi:10.1155/2021/6135920

Abstract

The green synthesis of silver nanoparticles (AgNPs) using plant extract, the cost-effective solution, and the abundance and environmental issue have been gaining much attention to scientists. Ganoderma lucidum (GL) commonly known as Lingzhi in Chinese and Reishi in Japanese, with a proven anticancer benefit, is discovered in the buffer zone of Bach Ma National Park, Nam Dong district, Thua Thien Hue province. In this work, the AgNPs were synthesized in a simple and effective biochemical reduction process using GL which is one of the biological organisms, as a reducing and stable agent. The optimum conditions of various experimental parameters such as pH, reaction time, concentration, and temperature were investigated. Obtained AgNPs were characterized by UV-Vis, FTIR, SEM, energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The effects of AgNP/GL materials and GL aqueous extraction on the antiproliferative activities of HepG2 and MCF-7 cells were studied. The novel AgNP/GL-based multicomponent suspension is a key compound that could find a good application in the medical and pharmaceutical sciences.

Highlights

Cancer is a disease caused when the normal cell proliferation control is lost
The color of the Ganoderma lucidum (GL) aqueous extract was yellow before its treatment with silver nitrate solution
We demonstrated a novel and easy process for the synthesis of AgNPs using aqueous extraction of G. lucidum

Summary

Introduction

Cancer is a disease caused when the normal cell proliferation control is lost. There are a number of methods for treating cancer disease, they spend a lot of money cost and have more weak points such as the limitation on distinguishing between normal and diseased cells and elimination from the human body [3]. To solve this phenomenon, developing a new material with the ability to hold and release drugs in environments with suitable pH and temperature is essential [4]. Metal nanomaterials have received a great deal of scientist’s concern [5]

Methods

Results

Conclusion