Abstract
Biocompatible zinc oxide nanoparticles were prepared using a simple co-precipitation method. Through this method, the synthesized zinc oxide nanoparticles that are of uniform size and highly crystalline in nature. The particle formation and stability were confirmed with UV–visible spectrometry and the functional groups which present in the particles were identified with FT-IR analysis. The particle size was confirmed with DLS analysis and the charges of the particles were determined by Zeta analysis. Particle size and shape were depicted from SEM analysis. The characterized particles were highly effective against the 6-OHDA induced cell damage in SH-SY5Y cells. The synthesized particles were found to be highly compatible to the selected cells. It recovers the neural cell damage at the concentration of 50 μg/mL. Our formulation thus can be used as an effective drug system for neurotherapy in near future Furthermore, it was found to be capable of inhibiting apoptotic activities in the selected SH-SY5Y cells thus it execute the damage recovery mechanism. Taken as a whole, our synthesized nanomaterials significantly recover the SH-SY5Y cells from 6-OHDA induced cell damage in in vitro system. Further evaluation should be needed to optimize the prepared nanomaterials as a candidate for treating various neural related diseases.
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