Abstract
Heterocyclic Chemistry is a vast thrust area for researchers. Various publications on biologically active phenothiazines and their ribofuranosides in recent years have aroused the interest of scientists in the synthesis and biological activity of these heterocycles. This article reports synthesis of some new prospective bioactive 10H-phenothiazines, their sulfones and ribofuranosides that have shown significant antimicrobial activity against some selected strains of fungi, Gram positive and gram negative bacteria and lead us to develop a possibly potent class of antimicrobial agents. 10H-phenothiazines were prepared via Smiles rearrangement. Their sulfones and ribofuranosides were prepared by oxidation with 30% hydrogen peroxide in glacial acetic acid and reaction with b-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar) respectively.
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