Synthesis of Bio-Compatible SPION-based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia.

A P Reena Mary,D Sakthikumar,P A Joy,T N Narayanan,Yasuhiko Yoshida,Vijutha Sunny,M R Anantharaman

doi:10.1007/s11671-010-9729-4

Abstract

Bio-compatible magnetic fluids having high saturation magnetization find immense applications in various biomedical fields. Aqueous ferrofluids of superparamagnetic iron oxide nanoparticles with narrow size distribution, high shelf life and good stability is realized by controlled chemical co-precipitation process. The crystal structure is verified by X-ray diffraction technique. Particle sizes are evaluated by employing Transmission electron microscopy. Room temperature and low-temperature magnetic measurements were carried out with Superconducting Quantum Interference Device. The fluid exhibits good magnetic response even at very high dilution (6.28 mg/cc). This is an advantage for biomedical applications, since only a small amount of iron is to be metabolised by body organs. Magnetic field induced transmission measurements carried out at photon energy of diode laser (670 nm) exhibited excellent linear dichroism. Based on the structural and magnetic measurements, the power loss for the magnetic nanoparticles under study is evaluated over a range of radiofrequencies.

Highlights

Colloidal suspensions of ultrafine magnetic particles have widespread applications in fields of both engineering [1,2,3] and biomedicine [3,4,5,6]
We report the synthesis of highly stable water-based iron oxide fluid with narrow particle size distribution at neutral pH, and the evaluation of magnetic properties for hyperthermia application
The X-ray diffraction pattern (Fig. 1) shows that the iron oxide particles have crystallized in the inverse spinel structure with a lattice constant of 8.41A

Summary

Introduction

Colloidal suspensions of ultrafine magnetic particles (ferrofluids) have widespread applications in fields of both engineering [1,2,3] and biomedicine [3,4,5,6]. Aqueous ferrofluids of superparamagnetic iron oxide nanoparticles with narrow size distribution, high shelf life and good stability is realized by controlled chemical co-precipitation process. The particle size, and its distribution, the magnetic and flow properties of the fluid influence the application parameters especially in biomedicine.

Results

Conclusion