Abstract
The synthesis, characterization, and antibacterial and antioxidant activity of thiadiazole-deoxycholic/lithocholic acid conjugates are described in this communication. The structures of the synthesised bile acid-thiadiazole conjugates were studied using 1H NMR, 13C NMR and FTIR. Compounds 4c (IC50; 15.34 ± 0.07 μM) and 5c (IC50; 13.45 ± 0.25 μM) demonstrated greater antioxidant activity than the reference compound ascorbic acid (IC50; 20.72 ± 1.02 μM) in DPPH assay. The most effective conjugates against P. vulgarise were 4c (IC50; 24 ± 2.3 μM), 4 g (IC50; 29 ± 2.5 μM), and 5c (IC50; 93 ± 3.6 μM), whereas the most effective conjugates against E. coli were 4e (IC50; 55 ± 2.1 μM) and 4f (IC50; 52 ± 3.5 μM). Conjugates 4c and 5c were the most effective against B. megaterium of all the synthesised conjugates, with IC50 values of 15 ± 1.08 and 20 ± 1.1 μM, respectively. Thus, a large library of compounds derived from bile acid can be easily synthesised for extensive structure–activity relationship studies in order to identify the most appropriate antibacterial agents and antioxidant activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
