Abstract
The synthesis of biheteroaryl derivatives by palladium-catalysed Suzuki cross-coupling reaction of heteroaryl bromides with heteroarylboronic acids is a challenging reaction due to the electronic and/or poisoning properties of these heteroaryl compounds. Through the use of [PdCl(C 3H 5)] 2/ cis, cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as a catalyst, a range of heteroaryl bromides undergoes Suzuki reaction with heteroarylboronic acids such as thiophene-, furan- or pyridineboronic acid derivatives in good yields. This catalyst can be used at low loadings with several substrates. In general bromopyridines were found to be more reactive than bromothiophenes or bromofuranes.
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