Abstract
Bicyclic proline analogs have a wide range of biological uses. We report here our synthesis of bicyclic proline analogs using a formal [3 + 2] intramolecular aziridine-allylsilane cycloaddition reaction. This synthesis allows for the preparation of both 5-5 and 6-5 fused ring systems and should be amenable to the preparation of analogs with substitution on the carbocyclic ring.
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