Abstract
A palladium-catalyzed carbonylative approach to benzothiophene-3-carboxylic esters, starting from simple and readily available building blocks [2-(methylthio)phenylacetylenes, CO, an alcohol, and O2 (from air)], is reported. The process is catalyzed by the simple PdI2/KI catalytic system to give the desired products in fair to high yields (57-83%). Interestingly, the reaction also works nicely in the ionic liquid BmimBF4 as the solvent, with the possibility to recycle the catalytic system several times without appreciable loss of activity.
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