Abstract
AbstractAn efficient synthetic approach involving indole alkylation/Pictet‐Spengler cyclization was developed to form benzazepinoindole derivatives. The reactions proceeded smoothly with indoles, 2‐aminobenzyl alcohols, and aldehydes in the presence of TiCl4 as a Lewis acid catalyst. The developed one‐pot protocol is operationally simple and tolerates various functional groups. Furthermore, this mild and practical tandem reaction provides a direct route to access benzazepinoindole‐containing natural products and bioactive compounds.
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