Abstract
The Batzelladines are polycyclic guanidine alkaloids that interrupt protein-protein interactions. Of particular interest is their potential for application in AIDS treatments. Nagasawa and co-workers employed Ali’s sequential 1,3-dipolar cycloaddition of nitrones approach (S. K. Ali, M. I. Wazeer Tetrahedron Lett. 1993, 34, 137-140) to construct H, a precursor to the tricyclic guanidine core.
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