Abstract
Abstract A series of seven analogues of aspartyl pentapeptides has been synthesized in relation to the structural features of sweet peptides. The rule in the structure-taste relationships of di-, tri-, and tetrapeptides is inapplicable to the pentapeptides. All the pentapeptides were devoid of sweetness, though they satisfied the requirements for sweet peptides. The result indicates that oligopeptides can not fit a deep receptor pocket. The mode of interactions between sweet peptides and the receptor is drawn schematically.
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