Abstract
Summary The synthesis, affinities for 5-HT1A, 5-HT2, D, D2, α1 and α2 receptors and structure-activity relationships are described for a series of arylpiperazines substituted on the N-4 atom with an ω-(2-naphthothiazole)alkyl chain. The best affinity for 5-HT1A receptors was obtained for 1-(2-methoxyphenyl)piperazine derivatives with IC50 values in the range 3.2–12 nM; however, for all the reported compounds mixed 5-HT1A/D2/α affinities were observed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
