Abstract
Palladium-catalyzed decarboxylation coupling reaction between α-cyano aliphatic carboxylate salts with aryl chlorides, aryl bromides, or aryl triflates has been discovered. The reaction is competent for the synthesis of secondary, tertiary, and quaternary α-aryl nitriles utilizing cheap and low-toxic starting materials. This reaction is demonstrated to be useful to synthesize two drug molecules, Flurbiprofen and Anastrozole in gram scale, showcasing its applicability as an alternative choice of the Buchwald–Hartwig α-arylation reaction. The concept of decarboxylative α-arylation reaction was also extended to the synthesis of α-aryl acetate from malonate monoester salt.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
