Synthesis of antibacterial Janus sheets containing dual-active centers by quaternization fracture

Abstract

The prevention of bacterial adhesion and proliferation on substrate surfaces have been recently growing interest of scientists. Herein, hollow Janus copolymer microspheres (PSV JMs) containing hydrophilic sodium sulfonate groups (-SO 3 Na) on its outer surface and hydrophobic benzyl chloride groups (-C 6 H 5 -CH 2 Cl) on its inner surface, were first synthesized through interfacial polymerization. Furthermore, the antibacterial Janus copolymer sheets (PSVNN JSs) with contact/release-based dual-active centers were successfully synthesized by using the obtained PSV JMs for two-step quaternization with hexadecyl trimethyl ammonium bromide (CTAB) and hexadecyldimethylamine (HDMA). Notably, PSVNN JSs could be effectively obtained through reasonable control of several factors, including the ratio of hydrophilic and hydrophobic monomers, the amount of crosslinker and pore-forming agent. Moreover, the resultant PSVNN JSs exhibited higher antibacterial activity due to the quaternary ammonium salts (QASs) groups connected by ionic bond and covalent bonds, which has bright prospects in application in biomedical and environmental science. • The interfacial polymerization was employed to prepare the hollow Janus copolymer microspheres (PSV JMs). • The antibacterial Janus copolymer sheets (PSVNN JSs) with dual-active centers could be realized by quaternization fracture of PSV JMs. • The PSVNN JSs exhibited higher antibacterial activity because of the synergistic antibacterial effect. • The PSVNN JSs would be of considerable significance for the construction of highly efficient antibacterial materials.