Abstract
Reaction of β-oxoesters with PIFA leads to α-(iodophenyl) derivatives. These compounds are the starting point for the preparation of [b]-annulated benzofurane derivatives by copper-catalyzed C–O coupling reaction in the presence of K3PO4. Congeners annulated with five-, six-, and seven-membered rings as well as products with tetrahydropyrano- and -pyrido-annulation are prepared. In particular, the cyclopenta[b]benzofurane represents an interesting scaffold with respect to compounds active against SARS-CoV-2. The great potential of the scaffold in a medicinal chemistry context was confirmed by addressing four points of diversification.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
