Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor—Part I

Abstract

Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During our ongoing process development work on forodesine HCl several novel compounds were identified as possible impurities in the process. Herein we present the synthesis of three novel compounds ( 2– 4).