Abstract
The introduction of the p-nitrophenylethyl-(NPE) and p-nitrophenylethoxyxarbonyl- (NPEOC) group for amino and hydroxy protection of purine and pyrimidine arabinofuranosides and their interconversion into the corresponding 3′-phosphoramidite building blocks provided very effective starting materials for solid support oligoarabinonucleotide syntheses. A structural analogue of the Phage T5 histidine tRNA consisting of 78 nucleotide units has been synthesized in excellent yield and high purity.
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