Synthesis of an Antimicrobial Thioanthraquinone Compound to Produce Biodegradable Electrospun Mats for Tissue Engineering Purposes

Abstract

In the present study for the first time in the literature, novel S-substituted bioactive anthraquinone compound were synthesized with a new, easy and less energetic reaction method (Patent Number: TR2016/19610) from 1-chloro-9,10-dihydrodiagnosisxy-anthraquinone and butyl-3-mercaptopropionate. The resultant structure present remarkable biological properties It was purified by column chromatography. All obtained structures were characterized with spectroscopic methods (NMR, MS, FT-IR, UV etc). Antimicrobial properties of bioactive compound were determined as well. The resultant thioanthraquinone compound has been synthesized for the first time in the literature and its applications as a biomaterial were discussed in the present study. Subsequently, biodegradable electrospun mats were produced via electrospinning method for their usage in treatment as a biomaterial. Structural (FTIR), morphological (FEG-SEM) biological (antimicrobial and in-vitro tests) and mechanical (tensile testing) characterizations were conducted for these nanobiomaterials. Presenting an advantage of the novel antimicrobial compound, the produced electrospun nanobiocomposites exhibited remarkable biological, mechanical properties. With a purposeful compound synthesis and a subsequent nanobiocomposite production, the obtained electrospun mats are good canditates for biomaterials for tissue engineering purposes and wound healing materials.