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Abstract
This article reports the synthesis of a PAA-g-PLA amphiphilic graft polymer, which could self-assemble into large compound micelles in aqueous media for sustained release of MTX.
Highlights
Biodegradable polymers have received increased attention and have been seen as a promising solution to the plastic waste issue because they can be broken down to environmentallyfriendly low molecular weight products such as water and carbon oxide.[1,2] Among the many known biodegradable polymers, polylactides (PLAs) occupy a prominent position due to their biodegradability, biocompatibility, and ready availability from inexpensive renewable resources.[3,4,5,6,7,8] PLAs can be fabricated into sutures, catheters, and prosthetic devices, and recently their application in tissue engineering has been quite attractive.[9]
A well-defined amphiphilic graft copolymer consisting of a hydrophilic poly(acrylic acid) (PAA) backbone and hydrophobic poly(lactic acid) side chains was synthesized by the combination of reversible addition– fragmentation chain transfer (RAFT) polymerization, ring open polymerization (ROP), and the graftingfrom strategy
The hydrophobic PtBA backbone was transformed into a hydrophilic PAA backbone to afford the target well-defined PAA-g-PLA amphiphilic graft copolymer (Mw/Mn 1⁄4 1.17) containing -distributed carboxyls along the backbone
Summary
Biodegradable polymers have received increased attention and have been seen as a promising solution to the plastic waste issue because they can be broken down to environmentallyfriendly low molecular weight products such as water and carbon oxide.[1,2] Among the many known biodegradable polymers, polylactides (PLAs) occupy a prominent position due to their biodegradability, biocompatibility, and ready availability from inexpensive renewable resources.[3,4,5,6,7,8] PLAs can be fabricated into sutures, catheters, and prosthetic devices, and recently their application in tissue engineering has been quite attractive.[9]. None has ever reported the synthesis of PLA-based amphiphilic gra copolymers bearing a hydrophilic backbone whose every repeat unit is all hydrophilic for ensuring the equaled distribution of hydrophilic functionalities.
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