Abstract
Experimental conditions which influence the formation of α-aminosuccinimide (Asu) structures in Fmoc-based SPPS have been examined as part of our work on the synthesis of the hypoglycaemic peptide, Asu11-hGH[6–13] amide, and its analogues. Based on these investigations, experimental conditions for the acid- and base-catalysed cyclization of the corresponding protected aspartyl-containing peptides have been optimized to provide improved yields and reduced side product formation of these α-aminosuccinimide-containing peptides.
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