Synthesis of aminomethyl substituted silacyclohexanes from divinylsilanes: An unusually selective [formula omitted] sequence

Abstract

The preparation of aminomethyl substituted silacyclohexane derivatives starting from divinylsilanes and secondary amines is achieved in a selective one-pot tandem hydroformylation condensation sequence starting with a double olefin carbonylation and proceeding with an enamine generation followed by an aldol condensation step. Final hydrogenation leads to the silacycle in medium up to quantitative yields.