Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives

Abstract

2,5-Diaryl-4-(chloromethyl)imidazoline derivatives 5a-g, obtained from N-acyl-α-amino ketone derivatives 1, were rearranged with sodium hydride in dimethylformamide. Spontaneous air oxidation led to 2,4-di- and 2,4,6-triarylpyrimidine derivatives 6a-g in good yields