Abstract
A cloned human cutaneous lymphoma Hut102-B2 with helper T-cell phenotype (Leu1 +, Leu2a −, Leu3a +) was found to produce substantial quantities of interferon (IFN) on induction with the phorbol ester, 12- O-tetradecanoylphorbol-13-acetate (TPA). Whereas only trace amounts of IFN were secreted by Hut102-B2 cells spontaneously, up to 8000 laboratory units/ ml of IFN were synthesized under the optimal conditions of TPA induction. Characterization studies including neutralization by specific antisera to IFNs and determination of the activities in human and bovine cells disclosed that the IFN produced by Hut102-B2 cells exposed to TPA was a mixture of immune IFN (IFN-γ) and leukocyte IFN (IFN-α) made in approximately equal amounts in terms of antiviral activity.
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