Synthesis of α-alkynyl perfluoroalkyl sulfoxides by the reaction of terminal alkynes and perfluoroalkanesulfinyl chlorides

Abstract

The reaction of terminal alkynes with perfluoroalkanesulfinyl chlorides was achieved in the presence of n -BuLi/ZnCl 2 . A series of α-alkynyl perfluoroalkyl sulfoxides were synthesized for the first time in moderate to good yields via the nucleophilic substitution reaction of alkynylzinc chlorides formed in situ with perfluoroalkanesulfinyl chlorides. • The reaction of terminal alkynes with perfluoroalkanesulfinyl chlorides was firstly achieved. • α-Alkynyl perfluoroalkyl sulfoxides were synthesized for the first time. • Structurally diverse α-alkynyl perfluoroalkyl sulfoxides were obtained in good yields.