Abstract
A general alkylation protocol for substituted iodopyridines was developed (32 examples, 44–97% yield). The reaction is based on the Pd(II)-catalyzed C–H activation of 8-aminoquinoline-derived alkanoic amides and it employs a catalyst cocktail of Pd(OAc)<sub>2</sub> (10 mol%), NaI (30 mol%), and (BuO)<sub>2</sub>POOH (20 mol%), with Ag<sub>2</sub>CO<sub>3</sub> as base.
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