Synthesis of alkoxy derivatives of dodecahydro- closo-dodecaborate anion [B 12H 12] 2−

Abstract

Dodecahydro- closo-dodecaborate anion [B 12H 12] 2− is a stable non-toxic highly water-soluble boron-rich compound. Functionalized derivatives of this compound are of high interest as BNCT agents. There are however very few routes for the functionalizing of the cage. The present contribution describes a way to overcome this problem and to attach [B 12H 12] 2− to organic molecules including biomolecules. A number of alkoxy derivatives of dodecahydro- closo-dodecaborate anion [B 12H 11OR] 2− (R = Et, i-Pr, C 16H 33, allyl, benzyl, p-CH 2C 6H 4CN, p-CH 2C 6H 4NO 2, p-CH 2CH 2C 6H 4NO 2, and CH 2CH 2N(CO) 2C 6H 4) were prepared by the reaction of (Bu 4N) 2[B 12H 11OH] with the corresponding alkyl bromides or iodides in acetone in the presence of K 2CO 3. This route can be used for synthesis of water-soluble derivatives of the dodecahydro- closo-dodecaborate anion for potential use in Boron Neutron Capture Therapy. [Display omitted]