Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer

Bing Liu,Jing Qu,Jian Zhou,Bin Zhang

doi:10.1155/2019/6457968

Abstract

Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.

Highlights

Ovarian cancer is the fourth leading cause of cancer-related deaths among women, with an estimated 200,000 new cases, and 125,000 women die of ovarian cancer annually worldwide [1, 2]
Our results have shown that the Ag@Fe3O4 nanoparticles could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 under NIR laser irradiation and are exhibited independent of a concentration-time manner
In order to further examine the photothermal destruction of cancer cells, SKOV3 cells were treated with NIR laser illumination under different concentrations of the Ag@Fe3O4 nanoparticles

Summary

Introduction

Ovarian cancer is the fourth leading cause of cancer-related deaths among women, with an estimated 200,000 new cases, and 125,000 women die of ovarian cancer annually worldwide [1, 2]. Song et al have synthesized the Janus iron oxides @ semiconducting polymer nanoparticles, which were applied to cancer cell labeling and in vivo tracking by MPI and fluorescence imaging [20]. Among those nanomaterials, the Ag@Fe3O4 nanoparticles, a novel photothermal agent, are expected be a good candidate for photothermal therapy application due to their strong SPR absorption property, high photothermal conversion efficacy, and outstanding photothermal stability [21]. Analysis, the synthesized Ag@Fe3O4 nanoparticles show a high dispersion and photothermal effect Their efficacy in photothermal treatment for cancer under NIR laser irradiation is investigated by SKOV3 cells. Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment

Materials and Methods

Results and Discussion

Conclusion

Conflicts of Interest